Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome

Ann Epidemiol. 2012 Dec;22(12):892-4. doi: 10.1016/j.annepidem.2012.09.005. Epub 2012 Oct 11.

Abstract

Purpose: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress.

Methods: Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration.

Results: After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P = .04). The adjusted mean levels of 2,3-dinor-iPF2α-III were similar in DS individuals and controls (P = .7).

Conclusions: Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Allantoin / urine*
  • Biomarkers / urine*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Chromatography, Liquid
  • Down Syndrome / physiopathology
  • Down Syndrome / urine*
  • F2-Isoprostanes / urine*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress / physiology*
  • Tandem Mass Spectrometry
  • Young Adult

Substances

  • Biomarkers
  • F2-Isoprostanes
  • Allantoin