Fragment and conquer: from structure to complexes to function

Jean-François Guichou; Gilles Labesse

doi:10.1016/j.str.2012.09.008

Fragment and conquer: from structure to complexes to function

Structure. 2012 Oct 10;20(10):1617-9. doi: 10.1016/j.str.2012.09.008.

Authors

Jean-François Guichou¹, Gilles Labesse

Affiliation

¹ Atelier de Bio- et Chimie Informatique Structurale, CNRS, UMR5048, Centre de Biochimie Structurale, F-34090 Montpellier, France.

PMID: 23063007
DOI: 10.1016/j.str.2012.09.008

Abstract

In this issue of Structure, Shumilin and colleagues show the power of metabolite screening by means of X-ray crystallography to link an orphan protein domain with an orphan biochemical function. This result paves the way for large-scale functional annotation and sets new objectives for structural genomics.

Publication types

Comment
Research Support, Non-U.S. Gov't