Enzymatic transglycosylation of PEG brushes by β-galactosidase

Yan Fang; Wei Xu; Jian Wu; Zhi-Kang Xu

doi:10.1039/c2cc35369e

Enzymatic transglycosylation of PEG brushes by β-galactosidase

Chem Commun (Camb). 2012 Nov 25;48(91):11208-10. doi: 10.1039/c2cc35369e.

Authors

Yan Fang¹, Wei Xu, Jian Wu, Zhi-Kang Xu

Affiliation

¹ MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.

PMID: 23057072
DOI: 10.1039/c2cc35369e

Abstract

Enzymatic transglycosylation has been successfully implemented by β-galactosidase (β-Gal) on PEG brushes. Kinetic parameters validate this kind of chemoenzymatic strategy which is promising for construction of biomimetic surfaces with glycocalyx-like structures.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biocatalysis
Biomimetic Materials / chemistry
Biomimetic Materials / metabolism
Glycosylation
Kinetics
Polyethylene Glycols / chemistry*
beta-Galactosidase / chemistry
beta-Galactosidase / metabolism*

Substances

Polyethylene Glycols
beta-Galactosidase