Spectral characteristics of the hippocampal LFP during contextual fear conditioning

Einstein (Sao Paulo). 2012 Apr-Jun;10(2):140-4. doi: 10.1590/s1679-45082012000200005.
[Article in English, Portuguese]

Abstract

Objective: The hippocampus has an important role in the acquisition and recall of aversive memories. The objective of this study was to investigate the relationship among hippocampal rhythms.

Methods: Microeletrodes arrays were implanted in the hippocampus of Wistar rats. The animals were trained and tested in a contextual fear conditioning task. The training consisted in applying shocks in the legs. The memory test was performed 1 day (recent memory) or 18 days (remote memory) after training. We proposed a measure based on the FFT power spectrum, denominated "delta-theta ratio", to characterize the different behaviors (active exploration and freezing) and the memories types.

Results: The delta-theta ratio was able to distinguish recent and remote memories. In this study, the ratio for the 18-day group was smaller than for the 1-day group. Moreover, this measure was useful to distinguish the different behavior states - active exploration and freezing.

Conclusions: The results suggest delta-theta oscillations could reflect the demands on information processing during recent and remote memory recalls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Conditioning, Classical / physiology*
  • Fear / physiology*
  • Hippocampus / physiology*
  • Male
  • Mental Recall / physiology*
  • Microelectrodes
  • Rats
  • Rats, Wistar