A unique case of blastoid variant of mantle cell lymphoma with an aberrant CD5-/CD10+/Bcl-6+/CD56+ immunophenotype: a case report

Tumori. 2012 Jul-Aug;98(4):e111-4. doi: 10.1177/030089161209800424.

Abstract

The neural adhesion molecule CD56 is normally expressed on natural killer cells and subsets of T cells and is commonly found in hematolymphoid neoplasms. Expression of CD56 is very rare in B-cell lymphoma and most reported CD56-positive cases were diffuse large B-cell lymphomas. Cases of CD56-positive mantle cell lymphoma (MCL) have not previously been described in the literature. We present a case of CD56-positive MCL. To the best of our knowledge, this is the first case report of MCL expressing CD56.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis*
  • Biopsy
  • CD5 Antigens / analysis*
  • CD56 Antigen / analysis*
  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 14
  • DNA-Binding Proteins / analysis*
  • Female
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • In Situ Hybridization, Fluorescence
  • Lymphoma, Mantle-Cell / immunology*
  • Lymphoma, Mantle-Cell / pathology*
  • Middle Aged
  • Neprilysin / analysis*
  • Proto-Oncogene Proteins c-bcl-6
  • Tonsillar Neoplasms / immunology*
  • Tonsillar Neoplasms / pathology*
  • Translocation, Genetic

Substances

  • BCL6 protein, human
  • Biomarkers, Tumor
  • CD5 Antigens
  • CD56 Antigen
  • DNA-Binding Proteins
  • NCAM1 protein, human
  • Proto-Oncogene Proteins c-bcl-6
  • Neprilysin