RNAi screening of the human colorectal cancer genome identifies multifunctional tumor suppressors regulating epithelial cell invasion

Cell Res. 2012 Nov;22(11):1605-8. doi: 10.1038/cr.2012.140. Epub 2012 Oct 9.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenomatous Polyposis Coli Protein / genetics
  • Class I Phosphatidylinositol 3-Kinases
  • Colorectal Neoplasms / genetics*
  • Colorectal Neoplasms / pathology
  • Epithelial Cells / pathology*
  • Genes, Tumor Suppressor*
  • Genes, p53
  • Humans
  • Mutation
  • Neoplasm Invasiveness / genetics
  • Phosphatidylinositol 3-Kinases / genetics
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogene Proteins p21(ras)
  • RNA Interference*
  • RNA, Small Interfering
  • Sequence Analysis, DNA
  • ras Proteins / genetics

Substances

  • APC protein, human
  • Adenomatous Polyposis Coli Protein
  • KRAS protein, human
  • Proto-Oncogene Proteins
  • RNA, Small Interfering
  • Phosphatidylinositol 3-Kinases
  • Class I Phosphatidylinositol 3-Kinases
  • PIK3CA protein, human
  • Proto-Oncogene Proteins p21(ras)
  • ras Proteins