Abstract
When inflammation is induced in rats following injection of Freund's complete adjuvant, steady state levels of T-I and T-II kininogen mRNAs increase markedly as do plasma levels of T-I and T-II kininogens. When rats are additionally treated with dexamethasone, T-I and T-II steady state mRNA levels and plasma levels of T-kininogens are reduced. The results suggest that dexamethasone may affect the magnitude of T-kininogen gene induction caused by inflammation.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Autoradiography
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Base Sequence
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Blotting, Northern
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Dexamethasone / pharmacology*
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Dexamethasone / therapeutic use
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Female
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Freund's Adjuvant
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Inflammation / blood
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Inflammation / drug therapy*
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Kininogens / blood
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Kininogens / genetics*
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Male
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Molecular Sequence Data
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Oligonucleotide Probes
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Oligonucleotides / genetics
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RNA, Messenger / biosynthesis*
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Rats
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Rats, Inbred Strains
Substances
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Kininogens
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Oligonucleotide Probes
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Oligonucleotides
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RNA, Messenger
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Dexamethasone
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Freund's Adjuvant