Carbamazepine-induced bradycardia-tachycardia syndrome with pharmacological analysis and concurrent ECG monitoring

J Electrocardiol. 1990 Jan;23(1):85-8. doi: 10.1016/0022-0736(90)90154-t.

Abstract

The authors present a patient with carbamazepine-induced bradycardia-tachycardia syndrome, a rare type of drug-induced sinus node dysfunction. In this case, they established a clear-cut relationship between plasma carbamazepine concentration and the frequency of sinus arrests, following episodes of supraventricular tachycardia. As the pharmacological analysis of drug-induced sinus node dysfunction by concurrent ECG monitoring is very limited, the findings give an insight into the mechanism of this disorder.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Bradycardia / blood
  • Bradycardia / chemically induced*
  • Bradycardia / diagnosis
  • Carbamazepine / adverse effects*
  • Carbamazepine / blood
  • Electrocardiography
  • Female
  • Humans
  • Syndrome
  • Tachycardia, Supraventricular / blood
  • Tachycardia, Supraventricular / chemically induced*
  • Tachycardia, Supraventricular / diagnosis

Substances

  • Carbamazepine