Abstract
An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antibodies, Viral / blood*
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Antibody Formation*
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Antigens, Viral / immunology*
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Human Experimentation
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Humans
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Immunoassay / methods
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Norwalk virus / immunology*
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Peptide Hydrolases / immunology*
Substances
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Antibodies, Viral
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Antigens, Viral
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Peptide Hydrolases