Kikuchi-Fujimoto disease with cutaneous presentation in a patient with subacute cutaneous lupus erythematosus

Dermatol Online J. 2012 Sep 15;18(9):8.

Abstract

We report the case of a 45-year-old female patient previously diagnosed with subacute cutaneous lupus erythematosus who presented with a one-week history of fever, tender erythematous nodules on her limbs, and palpable lymphadenopathy. Two incisional biopsies showed histiocytic infiltrates with abundant nuclear debris in the dermis and at the dermosubcutaneous junction with absence of neutrophils, characteristic of Kikuchi-Fujimoto disease (KFD). The dermatologic and dermopathologic details of KFD are very heterogeneous and yet poorly described. We have reviewed the literature regarding KFD cases reported with cutaneous involvement trying to assess the skin features of the KFD or histiocytic necrotizing lymphadenitis.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Biopsy
  • Drug Therapy, Combination
  • Female
  • Histiocytes / drug effects
  • Histiocytic Necrotizing Lymphadenitis / drug therapy
  • Histiocytic Necrotizing Lymphadenitis / pathology*
  • Humans
  • Hydroxychloroquine / therapeutic use
  • Lupus Erythematosus, Cutaneous / drug therapy
  • Lupus Erythematosus, Cutaneous / pathology*
  • Lymphatic Diseases / diagnosis
  • Lymphatic Diseases / drug therapy
  • Lymphatic Diseases / pathology
  • Middle Aged
  • Naproxen / therapeutic use
  • Prednisone / therapeutic use
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Hydroxychloroquine
  • Naproxen
  • Prednisone