Anamnestic immunological response profile in laboratory animals after immunization with recombinant hepatitis B vaccines of different generations

Paulina Górska; Jacek Michałkiewicz; Bożenna Bucholc

doi:10.1016/j.biologicals.2012.08.001

Anamnestic immunological response profile in laboratory animals after immunization with recombinant hepatitis B vaccines of different generations

Biologicals. 2012 Nov;40(6):431-8. doi: 10.1016/j.biologicals.2012.08.001. Epub 2012 Sep 20.

Authors

Paulina Górska¹, Jacek Michałkiewicz, Bożenna Bucholc

Affiliation

¹ National Institute of Public Health - National Institute of Hygiene, Department of Sera and Vaccines Evaluation, Chocimska Str. 24, 00-791 Warsaw, Poland. pgorska@pzh.gov.pl

PMID: 22999385
DOI: 10.1016/j.biologicals.2012.08.001

Abstract

Hepatitis B vaccines containing preS1 and preS2 fragments are assumed to be more immunogenic than those containing SHBs protein alone, which may be of importance for immunization of people with poorly induced or without any immunological response after vaccination. The aim of this study was to evaluate: The following conclusions can be drawn on the basis of obtained results:

MeSH terms

Animals
Cytokines / biosynthesis
Hepatitis Antibodies / biosynthesis
Hepatitis B Vaccines / immunology*
Immunity, Cellular
Immunologic Memory*
Mice
Mice, Inbred BALB C
Vaccines, Synthetic / immunology*

Substances

Cytokines
Hepatitis Antibodies
Hepatitis B Vaccines
Vaccines, Synthetic