IDH1 mutations disrupt blood, brain, and barriers

Cancer Cell. 2012 Sep 11;22(3):285-7. doi: 10.1016/j.ccr.2012.08.022.

Abstract

The first two murine models of IDH1(R132H) mutation provide mechanistic insights into transformation. In hematopoietic cells, inhibition of TET2 and histone demethylases leads to epigenetic alterations and accumulation of hematopoietic precursors. In the central nervous system, inhibition of collagen and prolyl hydroxylases lead to altered microenvironment and defective angiogenesis.

MeSH terms

  • Animals
  • Brain / metabolism*
  • Cell Transformation, Neoplastic
  • Epigenesis, Genetic
  • Hematopoiesis
  • Hematopoietic Stem Cells / cytology*
  • Hematopoietic Stem Cells / physiology
  • Hematopoietic System / physiology*
  • Isocitrate Dehydrogenase / genetics*
  • Isocitrate Dehydrogenase / metabolism*
  • Mice
  • Models, Animal
  • Mutant Proteins / genetics
  • Mutant Proteins / metabolism
  • Mutation*
  • Neovascularization, Pathologic
  • Phenotype

Substances

  • Mutant Proteins
  • Isocitrate Dehydrogenase