Respiratory syncytial virus infection and chronic respiratory morbidity - is there a functional or genetic predisposition?

Acta Paediatr. 2012 Nov;101(11):1114-20. doi: 10.1111/j.1651-2227.2012.02825.x. Epub 2012 Sep 11.

Abstract

A systematic literature review has been undertaken. Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) in infancy is associated with chronic respiratory morbidity. Premorbid abnormal lung function may predispose to RVS LRTI in prematurely born infants.

Conclusion: Single-nucleotide polymorphisms in genes coding for IL-8, IL-19, IL-20, IL-13 mannose-binding lectin, IFNG and a RANTES polymorphism have been associated with subsequent wheeze following RSV LRTI in term-born infants.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Asthma / etiology*
  • Asthma / genetics
  • Asthma / physiopathology
  • Bronchiolitis, Viral / complications*
  • Chronic Disease
  • Cough / etiology
  • Cough / genetics
  • Cough / physiopathology
  • Disease Susceptibility* / physiopathology
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / etiology
  • Infant, Premature, Diseases / genetics
  • Infant, Premature, Diseases / physiopathology
  • Lung / physiopathology
  • Polymorphism, Single Nucleotide
  • Respiratory Function Tests
  • Respiratory Sounds / etiology*
  • Respiratory Sounds / genetics
  • Respiratory Sounds / physiopathology
  • Respiratory Syncytial Virus Infections / complications*

Substances

  • Genetic Markers