Chromatin 'resetting' during transcription elongation: a central role for methylated H3K36

Jill S Butler; Sharon Y R Dent

doi:10.1038/nsmb.2370

Chromatin 'resetting' during transcription elongation: a central role for methylated H3K36

Nat Struct Mol Biol. 2012 Sep;19(9):863-4. doi: 10.1038/nsmb.2370.

Authors

Jill S Butler¹, Sharon Y R Dent

Affiliation

¹ Department of Molecular Carcinogenesis at The Virginia Harris Cockrell Cancer Research Center, University of Texas MD Anderson Cancer Center, Smithville, Texas, USA.

Abstract

A number of events must occur to preserve the integrity of the chromatin template during gene transcription. A study in this issue reveals a novel mechanism whereby chromatin remodelers are recruited to histone modifications within gene bodies to prevent aberrant histone exchange during transcriptional elongation.

Publication types

Comment

MeSH terms

Adenosine Triphosphatases / metabolism*
Chromatin / metabolism*
DNA-Binding Proteins / metabolism*
Gene Expression Regulation, Fungal*
Histones / metabolism*
Saccharomyces cerevisiae / metabolism*
Saccharomyces cerevisiae Proteins / metabolism*

Substances

CHD1 protein, S cerevisiae
Chromatin
DNA-Binding Proteins
Histones
Saccharomyces cerevisiae Proteins
Adenosine Triphosphatases
ISW1 protein, S cerevisiae

Grants and funding

R01 GM067718/GM/NIGMS NIH HHS/United States