Structural biology: A protein engagement RING

Nature. 2012 Sep 6;489(7414):43-4. doi: 10.1038/489043a.

Abstract

The mechanistic details of the attachment of a small protein, ubiquitin, to other proteins are unclear. Crystal structures of the E2–ubiquitin and RING E3 enzymes, engaged and ready for transfer, provide fresh insights.

Publication types

  • News
  • Comment

MeSH terms

  • Animals
  • Biocatalysis*
  • Humans
  • Nuclear Proteins / chemistry*
  • Transcription Factors / chemistry*
  • Ubiquitin / metabolism*
  • Ubiquitin-Conjugating Enzymes / chemistry*
  • Ubiquitin-Conjugating Enzymes / metabolism*
  • Ubiquitin-Protein Ligases / chemistry*
  • Zinc Fingers*

Substances

  • Nuclear Proteins
  • Transcription Factors
  • Ubiquitin
  • UBE2D1 protein, human
  • Ubiquitin-Conjugating Enzymes
  • Rnf4 protein, rat
  • Ubiquitin-Protein Ligases