A 38-year-old woman presented with nausea and abdominal distension 15 months after surgical resection of osteoclast-like giant cell tumor in the left lobe of the liver. An 18F-FDG PET/CT scan was performed to evaluate the recurrent tumor. The images demonstrated the recurrent malignancy in the liver. In addition, metastatic lesions in both the abdomen and the chest were revealed.