Inv(14)(q11q32) in one of four different clones in a case of angioimmunoblastic lymphadenopathy

B Schlegelberger; A Feller; A Himmler; W Grote

doi:10.1016/0165-4608(90)90200-t

Inv(14)(q11q32) in one of four different clones in a case of angioimmunoblastic lymphadenopathy

Cancer Genet Cytogenet. 1990 Jan;44(1):77-81. doi: 10.1016/0165-4608(90)90200-t.

Authors

B Schlegelberger¹, A Feller, A Himmler, W Grote

Affiliation

¹ Department of Human Genetics, Christian Albrecht University, Kiel, Federal Republic of Germany.

PMID: 2293883
DOI: 10.1016/0165-4608(90)90200-t

Abstract

A case of angioimmunoblastic lymphadenopathy with dysproteinemia (AILD) with four cytogenetically different cell clones (49,XX,+5,+19,+21/47,XX,+X/46,XX,inv (14)(q11q32)/45,X,-X) is reported. To our knowledge, this is the first case of AILD with an inv(14)(q11q32), thus probably involving the T-cell receptor alpha-chain gene. The cytogenetic findings are discussed with respect to the possible progression of AILD to malignant lymphoma.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Banding
Chromosome Inversion*
Chromosomes, Human, Pair 14*
Female
Humans
Immunoblastic Lymphadenopathy / genetics*
Immunoblastic Lymphadenopathy / pathology
Karyotyping
Lymph Nodes / ultrastructure
Middle Aged