A synthetic method for palladium-catalyzed stannylation at the 5- and 6-benzo positions of indoles

Org Lett. 2012 Sep 7;14(17):4630-3. doi: 10.1021/ol302076d. Epub 2012 Aug 28.

Abstract

The stannylation of indole derivatives proceeds in good yields under palladium catalysis (5 mol %) without protection of the indolic nitrogen. The general utility of both PdCl(2)(PhCN)(2)/PCy(3) and Pd(2)dba(3)/PCy(3) as catalytic systems for the stannylation of three indole derivatives, with varying degrees of electron density, is presented.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Catalysis
  • Chemistry, Organic / methods*
  • Combinatorial Chemistry Techniques
  • Indoles / chemistry*
  • Molecular Structure
  • Organotin Compounds / chemical synthesis*
  • Organotin Compounds / chemistry
  • Palladium / chemistry*
  • Stereoisomerism

Substances

  • Indoles
  • Organotin Compounds
  • Palladium