Abstract
An amphiphilic water-soluble ytterbium complex which is photo-selective, functional and Golgi apparatus specific has been designed as a responsive dual probe capable of sensitizing emission within the biological window (660 and 750 nm), generating the singlet oxygen (Φ(Δ) = 0.45) and triggering local cell damage only upon exposure to visible and near-infrared laser excitation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Biosensing Techniques*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cyclams
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Golgi Apparatus / ultrastructure*
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HeLa Cells
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Heterocyclic Compounds / chemistry
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Humans
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Organometallic Compounds / chemistry*
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Organometallic Compounds / pharmacology
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Photochemotherapy*
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Porphyrins / chemistry
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Solubility
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Structure-Activity Relationship
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Water / chemistry
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Ytterbium / chemistry
Substances
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Antineoplastic Agents
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Cyclams
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Heterocyclic Compounds
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Organometallic Compounds
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Porphyrins
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Water
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cyclen
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Ytterbium