Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine

Alisson Martins-Oliveira; Flavia M Gonçalves; Jose G Speciali; Vanessa Fontana; Tatiane C Izidoro-Toledo; Vanessa A Belo; Fabiola Dach; Jose E Tanus-Santos

doi:10.1016/j.jneuroim.2012.07.016

Specific matrix metalloproteinase 9 (MMP-9) haplotype affect the circulating MMP-9 levels in women with migraine

J Neuroimmunol. 2012 Nov 15;252(1-2):89-94. doi: 10.1016/j.jneuroim.2012.07.016. Epub 2012 Aug 17.

Authors

Alisson Martins-Oliveira¹, Flavia M Gonçalves, Jose G Speciali, Vanessa Fontana, Tatiane C Izidoro-Toledo, Vanessa A Belo, Fabiola Dach, Jose E Tanus-Santos

Affiliation

¹ Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.

PMID: 22907074
DOI: 10.1016/j.jneuroim.2012.07.016

Abstract

We investigated whether three relevant polymorphisms (C-1562T, microsatellite -90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA had higher plasma MMP-9 concentrations than patients with MA. Patients with MA had the highest TIMP-1 and lowest MMP-9/TIMP-1 ratios. The MMP-9 "C L Q" haplotype was associated with higher plasma MMP-9 concentrations in migraine patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Enzyme-Linked Immunosorbent Assay
Female
Genetic Predisposition to Disease
Haplotypes
Humans
Matrix Metalloproteinase 9 / blood*
Matrix Metalloproteinase 9 / genetics*
Migraine Disorders / blood*
Migraine Disorders / genetics*
Polymorphism, Single Nucleotide
Reverse Transcriptase Polymerase Chain Reaction
Tissue Inhibitor of Metalloproteinase-1 / blood

Substances

Tissue Inhibitor of Metalloproteinase-1
Matrix Metalloproteinase 9