Notch and PI3K: how is the road traveled?

Blood. 2012 Aug 16;120(7):1349-50. doi: 10.1182/blood-2012-06-435099.

Abstract

In this issue of Blood,Wong et al present evidence that the Notch and phosphatidylinositol-3-kinase (PI3K) pathways cross-talk through a Hes1–phosphatase and tensin homolog (PTEN) axis during normal T-cell development.

Publication types

  • Comment

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / metabolism*
  • Cell Differentiation*
  • Homeodomain Proteins / metabolism*
  • PTEN Phosphohydrolase / metabolism*
  • Receptors, Antigen, T-Cell, alpha-beta / metabolism*
  • Thymocytes / cytology*
  • Thymocytes / enzymology*
  • Transcription Factor HES-1

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • Hes1 protein, mouse
  • Homeodomain Proteins
  • Receptors, Antigen, T-Cell, alpha-beta
  • Transcription Factor HES-1
  • PTEN Phosphohydrolase
  • Pten protein, mouse