Abstract
The crystal structure of a Wnt morphogen bound to its Frizzled receptor ectodomain provides insights into the evolutionary provenance of this complex fold and offers an explanation for why Wnts utilize both lipid- and protein-mediated contacts to engage Frizzleds.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Frizzled Receptors / chemistry
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Frizzled Receptors / metabolism
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Humans
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Models, Molecular
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Protein Structure, Quaternary
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Protein Structure, Tertiary
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Wnt Proteins / chemistry*
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Wnt Proteins / metabolism
Substances
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Frizzled Receptors
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Wnt Proteins