Evaluating the role of intra-operative radiation therapy in the modern management of breast cancer

M Barry; V Sacchini

doi:10.1016/j.suronc.2012.06.003

Evaluating the role of intra-operative radiation therapy in the modern management of breast cancer

Surg Oncol. 2012 Dec;21(4):e159-63. doi: 10.1016/j.suronc.2012.06.003. Epub 2012 Aug 11.

Authors

M Barry¹, V Sacchini

Affiliation

¹ Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 300 E. 66th St., New York, NY 10065, USA.

PMID: 22889742
DOI: 10.1016/j.suronc.2012.06.003

Abstract

Over the last 10 years, intra-operative radiotherapy (IORT) has been used extensively in the clinical trial setting but has yet to make a significant clinical impact on current breast cancer management strategies. This review discusses the rationale behind IORT, the benefits and limitations of this technique over conventional whole breast radiation (WBRT), and the indications, contraindications, and appropriate patient selection criteria. In addition, the most up-to-date trial data and the role of IORT in future breast cancer management strategies are discussed.

Publication types

Review

MeSH terms

Breast Neoplasms / radiotherapy*
Breast Neoplasms / surgery
Combined Modality Therapy
Disease Management
Female
Humans
Intraoperative Care / trends*
Mastectomy*
Radiotherapy, Adjuvant