[ROS induction and structural modification in human lymphocyte membrane under the influence of carbon nanotubes]

Biofizika. 2012 May-Jun;57(3):446-53.
[Article in Russian]

Abstract

To assess the potential risks of using the artificial nanostructures the structural state of the human lymphocyte membrane and lipid peroxidation under the influence of multi-walled carbon nanotubes with metal impurities was studied. The ability of carbon nanotubes to induce the formation of reactive oxygen species in cells was examined. A dose-dependent increase in reactive oxygen species formation in lymphocytes, which was not registered in cells pre-incubated with N-acetylcystein, after exposure to carbon nanotubes was shown. The addition of iron chelator deferoxamine to carbon nanotubes has also resulted in a decrease of reactive oxygen species. The mechanism of the activation of lipid peroxidation under the influence of carbon nanotubes and a structural modification of human lymphocyte membranes were discussed.

Publication types

  • English Abstract

MeSH terms

  • Acetylcysteine / pharmacology
  • Cell Membrane / drug effects
  • Cell Membrane / metabolism
  • Cell Survival / drug effects
  • Deferoxamine / pharmacology
  • Free Radical Scavengers / pharmacology
  • Humans
  • Iron / adverse effects
  • Iron / chemistry
  • Leukocytes, Mononuclear / metabolism
  • Lipid Peroxidation / drug effects
  • Lymphocytes / drug effects*
  • Lymphocytes / metabolism
  • Nanotubes, Carbon / adverse effects*
  • Nanotubes, Carbon / chemistry
  • Pyrenes
  • Reactive Oxygen Species / antagonists & inhibitors
  • Reactive Oxygen Species / metabolism*

Substances

  • Free Radical Scavengers
  • Nanotubes, Carbon
  • Pyrenes
  • Reactive Oxygen Species
  • pyrene
  • Iron
  • Deferoxamine
  • Acetylcysteine