The biodistribution pattern of [(11)C]Kendine 91 (a novel HDAC inhibitor) after IV administration has been evaluated using Positron Emission Tomography (rats) and gamma counting of dissected tissues (rats and mice) at different doses (1 μg/kg and 10.0 mg/kg). Metabolism in mice plasma has been also investigated by radio-HPLC. Obtained results (fast accumulation in lungs, heart, kidneys and liver; lower uptake in pancreas and muscle) are in concordance with previously reported results using HPLC/MS-MS. Plasma analysis studies showed a fast metabolism of the radiotracer.
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