Photodynamic activity of viral nanoparticles conjugated with C60

Chem Commun (Camb). 2012 Sep 18;48(72):9044-6. doi: 10.1039/c2cc34695h. Epub 2012 Aug 2.

Abstract

The development of viral nanoparticles (VNP) displaying multiple copies of the buckyball (C(60)) and their photodynamic activity is described. VNP-C(60) conjugates were assembled using click chemistry. Cell uptake and cell killing using white light therapy and a prostate cancer cell line is demonstrated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Click Chemistry
  • Fullerenes / chemistry*
  • Fullerenes / pharmacology*
  • Humans
  • Photochemotherapy / methods*
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / pharmacology*
  • Viruses / chemistry*

Substances

  • Fullerenes
  • Photosensitizing Agents
  • fullerene C60