Mounting evidence suggests that the quality of outcomes in long-term care can be improved by strengthening the leadership behaviors of nurses. Consequently, a reduction in the prevalence and incidence of pressure ulcers (PUs) is thought to be possible through a nurse-led, team-based approach. The purposes of this article were to (1) advocate for greater nurse-led interdisciplinary teamwork focusing on PU prevention and (2) describe how a transformational and practice-based framework can be used to guide the long-term care team to improve PU quality care outcomes. Application of nurse-led, team-conceptualized strategies enables interdisciplinary workers to partner and more effectively participate in PU prevention programs, thus deepening engagement in the organization's overall approach to achieving quality outcomes.