Should I stay or should I go? Chromodomain proteins seal the fate of heterochromatic transcripts in fission yeast

Kevin M Creamer; Janet F Partridge

doi:10.1016/j.molcel.2012.07.007

Should I stay or should I go? Chromodomain proteins seal the fate of heterochromatic transcripts in fission yeast

Mol Cell. 2012 Jul 27;47(2):153-5. doi: 10.1016/j.molcel.2012.07.007.

Authors

Kevin M Creamer¹, Janet F Partridge

Affiliation

¹ Department of Biochemistry, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.

PMID: 22840999
DOI: 10.1016/j.molcel.2012.07.007

Abstract

In this issue of Molecular Cell, Ishida et al. (2012) and Keller et al. (2012) show distinct outcomes for heterochromatic RNAs that bind different chromodomain proteins; Chp1 tethers transcripts to centromeres, whereas Swi6(HP1)-bound transcripts are evicted from chromatin and destroyed.

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