Sugar, sex, and TGF-β in diabetic nephropathy

Semin Nephrol. 2012 May;32(3):261-8. doi: 10.1016/j.semnephrol.2012.04.005.

Abstract

TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • AMP-Activated Protein Kinases / metabolism
  • Animals
  • Diabetic Nephropathies / metabolism*
  • Estradiol / metabolism*
  • Female
  • Glucose / metabolism*
  • Glucose Transport Proteins, Facilitative / metabolism
  • Humans
  • Male
  • Mice
  • Rats
  • Sex Factors
  • Signal Transduction
  • Sodium-Glucose Transport Proteins / metabolism
  • TOR Serine-Threonine Kinases / metabolism
  • Testosterone / metabolism*
  • Transforming Growth Factor beta / metabolism*

Substances

  • Glucose Transport Proteins, Facilitative
  • Sodium-Glucose Transport Proteins
  • Transforming Growth Factor beta
  • Testosterone
  • Estradiol
  • TOR Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Glucose