Synthesis of biologically active bridged diazabicycloheptanes

Curr Med Chem. 2012;19(31):5342-63. doi: 10.2174/092986712803833317.

Abstract

The chemistry underlying how diazabicycloheptanes are assembled is described, subdivided according to chemical structure of two types, the 3,6 diazabicyclo[3.1.1]heptane and the 2,5-diazabicyclo[2.2.1]heptane ring system. Detailed information on myriad of activities of compounds derived from the two scaffolds are reported.

Publication types

  • Review

MeSH terms

  • Analgesics / chemical synthesis
  • Analgesics / chemistry
  • Analgesics / metabolism
  • Analgesics / pharmacology
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antipsychotic Agents / chemical synthesis
  • Antipsychotic Agents / chemistry
  • Aza Compounds / chemistry*
  • Bacteria / drug effects
  • Bridged-Ring Compounds / chemistry*
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / metabolism
  • Heptanes / chemical synthesis
  • Heptanes / chemistry*
  • Heptanes / pharmacology
  • Immunosuppressive Agents / chemical synthesis
  • Immunosuppressive Agents / chemistry
  • Immunosuppressive Agents / metabolism
  • Protein Binding

Substances

  • Analgesics
  • Anti-Bacterial Agents
  • Antipsychotic Agents
  • Aza Compounds
  • Bridged-Ring Compounds
  • Enzyme Inhibitors
  • Heptanes
  • Immunosuppressive Agents