Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties

J Am Chem Soc. 2012 Oct 10;134(40):16464-7. doi: 10.1021/ja305988f. Epub 2012 Aug 1.

Abstract

Porphyrin-phospholipid conjugates were used to create photonic microbubbles (MBs) having a porphyrin shell ("porshe"), and their acoustic and photoacoustic properties were investigated. The inclusion of porphyrin-lipid in the MB shell increased the yield, improved the serum stability, and generated a narrow volumetric size distribution with a peak size of 2.7 ± 0.2 μm. Using an acoustic model, we calculated the porshe stiffness to be 3-5 times greater than that of commercial lipid MBs. Porshe MBs were found to be intrinsically suitable for both ultrasound and photoacoustic imaging with a resonance frequency of 9-10 MHz. The distinctive properties of porshe MBs make them potentially advantageous for a broad range of biomedical imaging and therapeutic applications.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Breast Neoplasms / diagnosis
  • Breast Neoplasms / diagnostic imaging*
  • Cell Line, Tumor
  • Contrast Media* / chemistry
  • Female
  • Fluorine Compounds / administration & dosage
  • Gases / administration & dosage
  • Humans
  • Mice
  • Microbubbles*
  • Phospholipids / chemistry
  • Photoacoustic Techniques*
  • Porphyrins* / chemistry
  • Ultrasonography

Substances

  • Contrast Media
  • Fluorine Compounds
  • Gases
  • Phospholipids
  • Porphyrins