Abstract
Virus-like particles (VLPs) have proven to be versatile platforms for chemical and genetic functionalization for a variety of purposes in biomedicine, catalysis, and materials science. We describe here the simultaneous modification of the bacteriophage Qβ VLP with a metalloporphyrin derivative for photodynamic therapy and a glycan ligand for specific targeting of cells bearing the CD22 receptor. This application benefits from the presence of the targeting function and the delivery of a high local concentration of singlet oxygen-generating payload.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Allolevivirus / chemistry*
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Allolevivirus / metabolism
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Animals
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CHO Cells
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Cell Survival / drug effects
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Cell Survival / radiation effects
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Click Chemistry
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Cricetinae
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Green Fluorescent Proteins / chemistry
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Green Fluorescent Proteins / metabolism
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Humans
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Inhibitory Concentration 50
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Nanocapsules / chemistry*
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Nanoparticles
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Particle Size
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Photochemotherapy*
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / pharmacology
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Polysaccharides / chemistry
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Polysaccharides / metabolism*
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Porphyrins / chemistry*
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Porphyrins / pharmacology
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Sialic Acid Binding Ig-like Lectin 2 / metabolism
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Sialic Acids / chemistry
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Sialic Acids / metabolism
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Singlet Oxygen
Substances
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CD22 protein, human
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Nanocapsules
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Photosensitizing Agents
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Polysaccharides
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Porphyrins
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Sialic Acid Binding Ig-like Lectin 2
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Sialic Acids
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Green Fluorescent Proteins
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Singlet Oxygen