Abstract
Fourteen human immunodeficiency virus (HIV)-infected patients receiving an atazanavir (ATV)-based antiretroviral regimen developed complicated cholelithiasis. ATV was found in biliary calculi in 8 of 11 cases: infrared spectrometry analysis of calculi revealed that ATV made up a median of 89% (range, 10%-100%) of the total calculus composition. Development and management of ATV-associated cholelithiasis are discussed.
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Anti-HIV Agents / administration & dosage
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Anti-HIV Agents / adverse effects*
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Atazanavir Sulfate
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Calculi / chemistry
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Cholelithiasis / chemically induced*
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Cholelithiasis / pathology*
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Female
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HIV Infections / complications*
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HIV Infections / drug therapy*
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Humans
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Male
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Middle Aged
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Oligopeptides / administration & dosage
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Oligopeptides / adverse effects*
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Pyridines / administration & dosage
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Pyridines / adverse effects*
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Spectrophotometry, Infrared
Substances
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Anti-HIV Agents
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Oligopeptides
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Pyridines
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Atazanavir Sulfate