The current state of therapeutic drug trials in pregnancy

Clin Pharmacol Ther. 2012 Aug;92(2):149-50. doi: 10.1038/clpt.2012.81.

Abstract

The majority of pregnant women take prescription drugs during their pregnancy. Given the multitude of physiologic changes incumbent in pregnancy, accurate clinical trial data on drugs in pregnancy are crucial. This report summarizes the 264 registered clinical trials in the past two years. With many of these drug trials being pharmacokinetic and placebo-controlled studies, therapeutic drug trials are becoming more common.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abnormalities, Drug-Induced / prevention & control
  • Adolescent
  • Adult
  • Clinical Trials as Topic*
  • Female
  • Humans
  • Maternal Exposure
  • Patient Selection
  • Practice Guidelines as Topic
  • Pregnancy
  • Pregnancy Complications / drug therapy*
  • Prenatal Exposure Delayed Effects / chemically induced
  • Prenatal Exposure Delayed Effects / prevention & control
  • Prescription Drugs / administration & dosage*
  • Prescription Drugs / adverse effects
  • Young Adult

Substances

  • Prescription Drugs