Copper sulfide nanoparticles as a new class of photoacoustic contrast agent for deep tissue imaging at 1064 nm

ACS Nano. 2012 Aug 28;6(8):7489-96. doi: 10.1021/nn302782y. Epub 2012 Jul 25.

Abstract

Photoacoustic tomography (PAT) is an emerging molecular imaging modality. Here, we demonstrate use of semiconductor copper sulfide nanoparticles (CuS NPs) for PAT with an Nd:YAG laser at a wavelength of 1064 nm. CuS NPs allowed visualization of mouse brain after intracranial injection, rat lymph nodes 12 mm below the skin after interstitial injection, and CuS NP-containing agarose gel embedded in chicken breast muscle at a depth of ~5 cm. This imaging approach has great potential for molecular imaging of breast cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Chickens
  • Contrast Media / chemical synthesis*
  • Copper* / chemistry
  • Materials Testing
  • Mice
  • Nanostructures / chemistry*
  • Photoacoustic Techniques / methods*
  • Rats
  • Ultrasonography / methods*

Substances

  • Contrast Media
  • Copper
  • cupric sulfide