The effect of some antiinflammatory drugs on collagen of rat skin

Pol J Pharmacol Pharm. 1990 Jan-Feb;42(1):39-42.

Abstract

Collagen content and mutual relationship between type I and type III collagens in the skin of rats chronically treated with some antiinflammatory drugs were evaluated. It was found that prednisone, colchicine, acetylsalicylic acid, indomethacin and phenylbutazone induce a decrease of collagen content in rat skin. In the case of prednisone, acetylsalicylic acid and phenylbutazone modification of type I to type III collagen ratio in rat skin was observed. These observations suggest that non-steroid antiinflammatory drugs may exert similar effects on skin collagen as steroid hormones.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Aspirin / pharmacology
  • Colchicine / pharmacology
  • Collagen / metabolism*
  • Female
  • Indomethacin / pharmacology
  • Phenylbutazone / pharmacology
  • Prednisone / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Skin / drug effects
  • Skin / metabolism*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Collagen
  • Phenylbutazone
  • Aspirin
  • Colchicine
  • Prednisone
  • Indomethacin