Enhancement of natural resistance of mice to Rhodococcus equi infection by Dextran Sulfate 500

Microbiol Immunol. 1990;34(8):697-701. doi: 10.1111/j.1348-0421.1990.tb01046.x.

Abstract

The effect of intraperitoneal injection of Dextran Sulfate 500 (DS-500, 500,000 Mr) on the intravenous clearance and host resistance to Rhodococcus equi in mice was studied. Contrary to the results seen with Listeria monocytogenes, DS-500 enhanced murine resistance to R. equi and altered organ distribution and clearance.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomycetales Infections / immunology*
  • Actinomycetales Infections / microbiology
  • Actinomycetales Infections / prevention & control
  • Animals
  • Dextran Sulfate / pharmacology*
  • Female
  • Immunity, Innate / drug effects
  • Listeriosis / immunology
  • Mice
  • Rhodococcus / immunology*
  • Rhodococcus / isolation & purification
  • Tissue Distribution

Substances

  • Dextran Sulfate