Karyotypic changes identified by HaeIII restriction endonuclease banding in a patient with M2 acute non-lymphoblastic leukemia

L Stuppia; G Palka; G Fioritoni; G Calabrese; P Guanciali Franchi; L D'Arcangelo; G Torlontano

doi:10.1002/gcc.2870010408

Karyotypic changes identified by HaeIII restriction endonuclease banding in a patient with M2 acute non-lymphoblastic leukemia

Genes Chromosomes Cancer. 1990 Mar;1(4):310-1. doi: 10.1002/gcc.2870010408.

Authors

L Stuppia¹, G Palka, G Fioritoni, G Calabrese, P Guanciali Franchi, L D'Arcangelo, G Torlontano

Affiliation

¹ Institute of Biology and Genetics, University of Chieti, Italy.

PMID: 2278962
DOI: 10.1002/gcc.2870010408

Abstract

A patient with acute non-lymphoblastic leukemia, FAB type M2, showed a complex karyotype involving chromosomes 1 and 11. The breakpoints could not be exactly identified by GTG and QFQ banding. A subsequent analysis with Alul and HaeIII restriction enzyme staining allowed the detection of a translocation of the heterochromatic region of chromosome 1 to 11q21.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Chromosome Banding / methods*
Deoxyribonucleases, Type II Site-Specific
Humans
Karyotyping
Leukemia, Myeloid, Acute / genetics*
Male
Translocation, Genetic / genetics

Substances

Deoxyribonucleases, Type II Site-Specific
GGCC-specific type II deoxyribonucleases