Carbon-carbon bond formation: palladium-catalyzed oxidative cross-coupling of N-tosylhydrazones with allylic alcohols

Abstract

In the zone: Pd-catalyzed oxidative cross-coupling of N-tosylhydrazones with allylic alcohols leads to CC bond formation. A palladium-carbene migratory insertion is proposed to play the key role in this transformation. The reaction proceeds with readily available starting materials to afford substituted alkenes in a highly stereoselective manner.