Abstract
In 1994, The American Journal of Pathology published a key article reporting that hypoxic retina produces vascular endothelial growth factor (VEGF), suggesting a role for VEGF in ocular neovascularization. Subsequent developments in anti-VEGF treatment for neovascular eye disease have improved visual outcomes and changed the standard of care in retinal medicine and ophthalmology.
Copyright © 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
Publication types
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Historical Article
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Angiogenesis Inhibitors / history*
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Angiogenesis Inhibitors / pharmacology
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Angiogenesis Inhibitors / therapeutic use*
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Animals
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Eye / blood supply*
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Eye / drug effects
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Eye / pathology
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History, 20th Century
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History, 21st Century
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Humans
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Neovascularization, Pathologic / drug therapy*
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Neovascularization, Pathologic / pathology
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Vascular Endothelial Growth Factor A / antagonists & inhibitors*
Substances
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Angiogenesis Inhibitors
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Vascular Endothelial Growth Factor A