The hippo pathway

Cold Spring Harb Perspect Biol. 2012 Aug 1;4(8):a011288. doi: 10.1101/cshperspect.a011288.

Abstract

The Hippo pathway regulates tissue growth, and inactivation of any of four key components (HPO, WTS, SAV, and MATS) results in tissue overgrowth. Cell junctions may also modulate the pathway's activity.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Communication / physiology*
  • Drosophila Proteins / metabolism*
  • Drosophila melanogaster
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Models, Biological*
  • Neurofibromin 2 / metabolism*
  • Protein Serine-Threonine Kinases / metabolism*
  • Signal Transduction / physiology*

Substances

  • Drosophila Proteins
  • Intracellular Signaling Peptides and Proteins
  • Neurofibromin 2
  • Protein Serine-Threonine Kinases
  • hpo protein, Drosophila