pH-responsive NIR enhanced drug release from gold nanocages possesses high potency against cancer cells

Chem Commun (Camb). 2012 Aug 7;48(61):7640-2. doi: 10.1039/c2cc33543c. Epub 2012 Jun 27.

Abstract

We report a smart therapeutic nanoplatform based on Fe(3)O(4)@CaP capped gold nanocages, which integrates magnetic targeting, photothermal therapy and chemotherapy for killing cancer cells. Combining photothermal- and chemo-therapy results in a synergistic effect in cancer treatment.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / administration & dosage*
  • Antibiotics, Antineoplastic / pharmacology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Delayed-Action Preparations / chemistry*
  • Doxorubicin / administration & dosage*
  • Doxorubicin / pharmacology
  • Gold
  • Humans
  • Hydrogen-Ion Concentration
  • Hyperthermia, Induced
  • Laser Therapy
  • Nanostructures / chemistry*
  • Neoplasms / therapy*

Substances

  • Antibiotics, Antineoplastic
  • Delayed-Action Preparations
  • Gold
  • Doxorubicin