Microstructure study of liposomes decorated by hydrophobic magnetic nanoparticles

Dan Qiu; Xueqin An; Zhiyun Chen; Xingyuan Ma

doi:10.1016/j.chemphyslip.2012.06.004

Microstructure study of liposomes decorated by hydrophobic magnetic nanoparticles

Chem Phys Lipids. 2012 Jul;165(5):563-70. doi: 10.1016/j.chemphyslip.2012.06.004. Epub 2012 Jun 20.

Authors

Dan Qiu¹, Xueqin An, Zhiyun Chen, Xingyuan Ma

Affiliation

¹ School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

PMID: 22728111
DOI: 10.1016/j.chemphyslip.2012.06.004

Abstract

Magnetoliposomes, consisting of liposomes and magnetic nanoparticles (MNPs), have been tailored as very promising delivery vehicles in biotechnology and biomedicine applications. In this paper, liposomes with hydrophobic MNPs were prepared. The hydrophobic MNPs were successfully embedded in the lipid bilayer, which was proved by the results obtained from transmission electron microscope, atomic force microscope, differential scanning calorimetry and steady state fluorescence measurements. Moreover, systematic researches were carried out to investigate the effects of hydrophobic MNPs concentration on the morphology and microstructure of liposomes. The results show that the lipid bilayer was saturated with the hydrophobic MNPs when the mass ratio of MNPs to lipid reached 0.002.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Hydrophobic and Hydrophilic Interactions*
Liposomes / chemistry*
Magnetite Nanoparticles / chemistry*
Membrane Fluidity
Models, Molecular
Molecular Conformation
Transition Temperature

Substances

Liposomes
Magnetite Nanoparticles