Abstract
Multiple transposons, integrons and carbapenemases were found in Klebsiella pneumoniae colistin-resistant isolates as well as a genomic resistance island of the AbaR type in Acinetobacter baumannii colistin-resistant isolates from different hospitals from Buenos Aires City. PFGE analysis showed a polyclonal dissemination of antimicrobial resistance mechanisms among K. pneumoniae isolates, while in A. baumannii isolates the epidemic clone 1 from South America was found. Resistance determinants associated with horizontal gene transfer are contributing to the evolution to pandrug resistance in both epidemic and sporadic clones.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acinetobacter Infections / epidemiology
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Acinetobacter Infections / microbiology*
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Acinetobacter baumannii / drug effects*
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Acinetobacter baumannii / genetics
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Acinetobacter baumannii / metabolism
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Anti-Bacterial Agents / pharmacology
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Argentina / epidemiology
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Colistin / pharmacology
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Cross Infection / epidemiology
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Cross Infection / microbiology*
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DNA Transposable Elements
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Drug Resistance, Bacterial
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Epidemics
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Gene Expression Regulation, Bacterial
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Hospitals
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Humans
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Integrons
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Klebsiella Infections / epidemiology
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Klebsiella Infections / microbiology*
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Klebsiella pneumoniae / drug effects*
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Klebsiella pneumoniae / genetics
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Klebsiella pneumoniae / metabolism
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South America
Substances
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Anti-Bacterial Agents
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DNA Transposable Elements
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Colistin