Abstract
From the EtOH extract of the flowers of Camellia nitidissima Chi, a new acylated flavonoid glycoside, quercetin 7-O-(6"-O-E-caffeoyl)-β-D-glucopyranoside (1), has been isolated, together with three known flavonoids: quercetin (2), quercetin 3-O-β-D-glucopyranoside (3), and quercetin 7-O-β-D-glucopyranoside (4). Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 was shown to inhibit proliferation and to induce apoptosis of human lymphoma U937 cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Apoptosis / drug effects
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Camellia / chemistry*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Flowers / chemistry
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Quercetin / analogs & derivatives*
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Quercetin / chemistry
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Quercetin / isolation & purification
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Quercetin / pharmacology
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Stereoisomerism
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U937 Cells
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Glucosides
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quercetin 7-O-6''-(E-caffeoyl)-beta-D-glucopyranoside
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quercetin 7-O-glucopyranoside
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Quercetin