RuH2(CO)(PPh3)3 catalyzed selective formation of 1,4-disubstituted triazoles from cycloaddition of alkynes and organic azides

J Org Chem. 2012 Jul 6;77(13):5844-9. doi: 10.1021/jo3008572. Epub 2012 Jun 15.

Abstract

The ruthenium hydride complex RuH(2)(CO)(PPh(3))(3) was found to be an effective catalyst for the cycloaddition reactions of terminal alkynes and azides. In the presence of RuH(2)(CO)(PPh(3))(3), various azides reacted with a range of terminal alkynes to produce 1,4-disubstituted 1,2,3-triazoles with 100% selectivity and moderate to excellent yields.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Azides / chemistry*
  • Catalysis
  • Cyclization
  • Molecular Structure
  • Organometallic Compounds / chemistry*
  • Ruthenium / chemistry*
  • Triazoles / chemical synthesis*
  • Triazoles / chemistry

Substances

  • Alkynes
  • Azides
  • Organometallic Compounds
  • Triazoles
  • Ruthenium