Short term anti-tubercular drug therapy and hepatic microsomal enzyme activity. Antipyrine metabolism as an index

J Assoc Physicians India. 1990 Sep;38(9):631-2.

Abstract

The effect of short course chemotherapy on the drug metabolising capacity of the liver was studied in 7 newly diagnosed pulmonary tuberculosis patients, using antipyrine as a model drug. Antipyrine elimination half-life and plasma clearance rate were not significantly altered by 3 weeks of therapy. It is concluded that short course chemotherapy does not affect antipyrine metabolising enzyme activity.

MeSH terms

  • Adult
  • Antipyrine / analysis*
  • Antipyrine / metabolism
  • Antitubercular Agents / therapeutic use*
  • Drug Evaluation
  • Humans
  • Male
  • Microsomes, Liver / drug effects
  • Microsomes, Liver / enzymology*
  • Saliva / chemistry
  • Time Factors
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / metabolism

Substances

  • Antitubercular Agents
  • Antipyrine