Impaired osteogenic differentiation of mesenchymal stem cells derived from multiple myeloma patients is associated with a blockade in the deactivation of the Notch signaling pathway

Leukemia. 2012 Dec;26(12):2546-9. doi: 10.1038/leu.2012.126. Epub 2012 May 8.
No abstract available

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Marrow / metabolism
  • Bone Marrow / pathology*
  • Cell Differentiation*
  • Colony-Forming Units Assay
  • Fetus / pathology
  • Humans
  • Mesenchymal Stem Cells / metabolism
  • Mesenchymal Stem Cells / pathology*
  • Mice
  • Mice, Inbred C57BL
  • Multiple Myeloma / metabolism
  • Multiple Myeloma / pathology*
  • Osteogenesis*
  • Receptors, Notch / antagonists & inhibitors*
  • Receptors, Notch / genetics
  • Signal Transduction
  • Tumor Cells, Cultured

Substances

  • Receptors, Notch