Rheumatoid arthritis. Evidence for a genetic component to disease severity in RA

Nat Rev Rheumatol. 2012 May 31;8(6):312-3. doi: 10.1038/nrrheum.2012.74.

Abstract

Rheumatoid arthritis (RA) is partly heritable; genetic and serological markers are known to confer risk of developing pathology. But given clinical heterogeneity in RA, can we predict who will develop severe disease? Substantial heritability of erosive progression rates has now been identified, but better prognostic biomarkers remain wanting.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / diagnosis
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / physiopathology
  • Disease Progression
  • Family Health
  • Genetic Predisposition to Disease*
  • Humans
  • Prognosis
  • Quantitative Trait, Heritable*
  • Risk Factors
  • Severity of Illness Index*