Photosensitizer-incorporated G-quadruplex DNA-functionalized magnetofluorescent nanoparticles for targeted magnetic resonance/fluorescence multimodal imaging and subsequent photodynamic therapy of cancer

Meili Yin; Zhenhua Li; Zhen Liu; Jinsong Ren; Xinjian Yang; Xiaogang Qu

doi:10.1039/c2cc32129g

Photosensitizer-incorporated G-quadruplex DNA-functionalized magnetofluorescent nanoparticles for targeted magnetic resonance/fluorescence multimodal imaging and subsequent photodynamic therapy of cancer

Chem Commun (Camb). 2012 Jul 4;48(52):6556-8. doi: 10.1039/c2cc32129g. Epub 2012 May 24.

Authors

Meili Yin¹, Zhenhua Li, Zhen Liu, Jinsong Ren, Xinjian Yang, Xiaogang Qu

Affiliation

¹ State Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.

PMID: 22622597
DOI: 10.1039/c2cc32129g

Abstract

A smart heteronanostructure has been constructed for targeted photodynamic therapy and magnetic fluorescent imaging of cancer cells using photosensitizer-incorporated G-quadruplex DNA functionalized magnetic nanoparticles.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Breast Neoplasms / diagnosis*
Breast Neoplasms / therapy*
Cell Line, Tumor
Female
Fluorescent Dyes / chemistry
Fluorescent Dyes / therapeutic use
G-Quadruplexes*
Humans
Magnetic Resonance Imaging
Magnets / chemistry
Mice
NIH 3T3 Cells
Nanoparticles / chemistry
Nanoparticles / therapeutic use*
Nanoparticles / ultrastructure
Photochemotherapy / methods*
Photosensitizing Agents / chemistry
Photosensitizing Agents / therapeutic use*

Substances

Fluorescent Dyes
Photosensitizing Agents